If you happen to be a fan of Nintendo's classic handheld, I'm guessing we don't need to do the hard sell on the TravelBoy Backpack, which is obviously inspired by that very thing.
Perfect for fans of retro gaming, the bag replicates the handheld (with the exception of any company branding, obviously), complete with screen, pad and buttons. If this doesn't get you noticed in the morning rush, we don't know what will.
Both front and back are padded to protect your daily essentials, while (adjustable) straps and a handle make it easy to carry. On a more practical note, there is plenty of space, with a main compartment, a padded area, top pouch, middle pouch, bottom pouch and a pen / stylus area.
Not that any of the above matters, you'll be buying this purely for the design. $39.99 gets you one at ThinkGeek, which ships worldwide.